abstract：BACKGROUND:Many migraineurs who seek care in headache clinics are refractory to treatment, despite advances in headache therapies. Epidemiology is poorly characterized, because diagnostic criteria for refractory migraine were not available until recently. We aimed to determine the frequency of refractory migraine in pa...

journal_title：BMC neurology

authors： Irimia P,Palma JA,Fernandez-Torron R,Martinez-Vila E

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The mechanisms underlying the interictal habituation deficit of cortical visual evoked potentials (VEP) in migraine are not well understood. Abnormal long-term functional plasticity of the visual cortex may play a role and it can be assessed experimentally by light deprivation (LD). METHODS:We have compared...

journal_title：BMC neurology

authors： Coppola G,Crémers J,Gérard P,Pierelli F,Schoenen J

更新日期：2011-07-27 00:00:00

abstract：BACKGROUND:Myotonic dystrophy type 1 (MD1) is one of the most prevalent neuromuscular diseases, yet very little is known about how MD1 affects the lives of couples and how they themselves manage individually and together. To better match health care to their problems, concerns and needs, it is important to understand t...

journal_title：BMC neurology

authors： Cup EH,Kinébanian A,Satink T,Pieterse AJ,Hendricks HT,Oostendorp RA,van der Wilt GJ,van Engelen BG

更新日期：2011-07-13 00:00:00

abstract：BACKGROUND:There is much discourse in healthcare about the importance of client-centred rehabilitation, however in the realm of community-based therapy post-stroke there has been little investigation into the efficacy of goal-directed practice that reflects patients' valued activities. In addition, the effect of active...

journal_title：BMC neurology

authors： Graven C,Brock K,Hill K,Ames D,Cotton S,Joubert L

更新日期：2011-06-18 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the diagnostic accuracy (sensitivity and specificity) of clinical, imaging and motor evoked potentials (MEP) for predicting the short-term prognosis of multiple sclerosis (MS). METHODS:We obtained clinical data, MRI and MEP from a prospective cohort of 51 patients and 20 ...

journal_title：BMC neurology

authors： Bejarano B,Bianco M,Gonzalez-Moron D,Sepulcre J,Goñi J,Arcocha J,Soto O,Del Carro U,Comi G,Leocani L,Villoslada P

更新日期：2011-06-07 00:00:00

abstract：BACKGROUND:There is need for a cognitive test battery that can be easily used in clinical practice to detect or monitor cognitive performance in patients with multiple sclerosis (MS). In order to conduct, in this patient group, a preliminary investigation of the validity and utility of a brief computerized battery, the...

journal_title：BMC neurology

authors： Edgar C,Jongen PJ,Sanders E,Sindic C,Goffette S,Dupuis M,Jacquerye P,Guillaume D,Reznik R,Wesnes K

更新日期：2011-06-07 00:00:00

abstract：BACKGROUND:Recovery patterns of upper extremity motor function have been described in several longitudinal studies, but most of these studies have had selected samples, short follow up times or insufficient outcomes on motor function. The general understanding is that improvements in upper extremity occur mainly during...

journal_title：BMC neurology

authors： Alt Murphy M,Persson HC,Danielsson A,Broeren J,Lundgren-Nilsson A,Sunnerhagen KS

更新日期：2011-05-25 00:00:00

abstract：BACKGROUND:Multiple pathogenic factors may contribute to the pathophysiology of Alzheimer's disease (AD). Peripheral blood markers have been used to assess biochemical changes associated with AD and mild cognitive impairment (MCI) and involved in their pathophysiology. METHODS:Plasma samples and clinical data were obt...

journal_title：BMC neurology

authors： Kim SM,Song J,Kim S,Han C,Park MH,Koh Y,Jo SA,Kim YY

更新日期：2011-05-12 00:00:00

abstract：BACKGROUND:Although free radicals have been reported to play a role in the expansion of ischemic brain lesions, the effect of free radical scavengers is still under debate. In this study, the temporal profile of ischemic stroke lesion sizes was assessed for more than one year to evaluate the effect of edaravone which m...

journal_title：BMC neurology

authors： Nakase T,Yoshioka S,Suzuki A

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:Study aimed at investigation of pathogenic role and prognostic value of several selected cerebrospinal fluid acute phase factors that can reflect the severity of ischemic brain damage. METHODS:Ninety five acute ischemic stroke patients were investigated. Ischemic region visualized at the twenty fourth hour ...

journal_title：BMC neurology

authors： Beridze M,Sanikidze T,Shakarishvili R,Intskirveli N,Bornstein NM

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:Spinal muscular atrophy (SMA) is an autosomal recessive disorder that affects the motoneurons of the spinal anterior horn, resulting in hypotonia and muscle weakness. The disease is caused by deletion or mutation in the telomeric copy of SMN gene (SMN1) and clinical severity is in part determined by the copy...

journal_title：BMC neurology

authors： Darbar IA,Plaggert PG,Resende MB,Zanoteli E,Reed UC

更新日期：2011-03-24 00:00:00

abstract：BACKGROUND:The available health resources limit the amount of therapy that may be offered to children with cerebral palsy and the amount of training in each session may be insufficient to drive the neuroplastic changes, which are necessary for functional improvements to take place. The aim of this pilot study was to pr...

journal_title：BMC neurology

authors： Bilde PE,Kliim-Due M,Rasmussen B,Petersen LZ,Petersen TH,Nielsen JB

更新日期：2011-03-09 00:00:00

abstract：BACKGROUND:The major difficulty in postoperative care in patients after craniotomy is to distinguish the intracranial deficits from the residual effect of general anesthesia. In present study, we used cerebral state index (CSI) monitoring in patients after craniotomy with delayed recovery, and evaluated the prediction ...

journal_title：BMC neurology

authors： Xu M,Lei YN,Zhou JX

更新日期：2011-01-27 00:00:00

abstract：BACKGROUND:Patients frequently fail to receive adequate pain relief from, or are intolerant of, first-line therapies prescribed for neuropathic pain (NeP). This refractory chronic pain causes psychological distress and impacts patient quality of life. Published literature for treatment in refractory patients is sparse ...

journal_title：BMC neurology

authors： Plested M,Budhia S,Gabriel Z

更新日期：2010-11-19 00:00:00

abstract：BACKGROUND:MS-pathogenesis is known to involve both multiple environmental events, and several independent genetic risk-factors. METHODS:A model of susceptibility is developed and a mathematical analysis undertaken to elucidate the nature of genetic susceptibility to MS and to understand the constraints that are place...

journal_title：BMC neurology

authors： Goodin DS

更新日期：2010-10-28 00:00:00

abstract：BACKGROUND:Postherpetic neuralgia (PHN) is a painful and difficult to treat complication of acute herpes zoster. Current treatment options provide only partial relief and are often limited by poor tolerability. We evaluated the safety and efficacy of a single 60-minute application of NGX-4010, an 8% capsaicin patch, in...

journal_title：BMC neurology

authors： Webster LR,Tark M,Rauck R,Tobias JK,Vanhove GF

更新日期：2010-10-11 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is common and highly heritable with many genes and gene variants associated with AD in one or more studies, including APOE ε2/ε3/ε4. However, the genetic backgrounds for normal cognition, mild cognitive impairment (MCI) and AD in terms of changes in cerebrospinal fluid (CSF) levels o...

journal_title：BMC neurology

authors： Han MR,Schellenberg GD,Wang LS,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2010-10-08 00:00:00

abstract：BACKGROUND:Human serum paraoxonase 1 (PON1) plays a major role in the metabolism of several organophosphorus compounds. The enzyme is encoded by the polymorphic gene PON1, located on chromosome 7q21.3. Aiming to identify genetic variations related to the risk of developing brain tumors, we investigated the putative ass...

journal_title：BMC neurology

authors： Martínez C,Molina JA,Alonso-Navarro H,Jiménez-Jiménez FJ,Agúndez JA,García-Martín E

更新日期：2010-08-19 00:00:00

abstract：BACKGROUND:The disease burden of human immunodeficiency virus (HIV)--acquired immunodeficiency syndrome (AIDS) is highest in sub-Saharan Africa but there are few studies on the associated neurocognitive disorders in this region. The objectives of this study were to determine whether Western neuropsychological (NP) meth...

journal_title：BMC neurology

authors： Kanmogne GD,Kuate CT,Cysique LA,Fonsah JY,Eta S,Doh R,Njamnshi DM,Nchindap E,Franklin DR Jr,Ellis RJ,McCutchan JA,Binam F,Mbanya D,Heaton RK,Njamnshi AK

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:Overweight is reported as a side effect of SDR. The aims were to study the development of weight, height and body mass index (BMI) during five years after SDR. METHODS:This prospective, longitudinal and practice-based study included all 56 children with CP spastic diplegia undergoing SDR from the start in M...

journal_title：BMC neurology

authors： Westbom L,Lundkvist Josenby A,Wagner P,Nordmark E

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants for the treatment of depression in patients with Parkinson's Disease (PD) but data on their efficacy are controversial. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials ...

journal_title：BMC neurology

authors： Skapinakis P,Bakola E,Salanti G,Lewis G,Kyritsis AP,Mavreas V

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:Data from different studies suggest a favourable association between pretreatment with statins or hypercholesterolemia and outcome after ischaemic stroke. We examined whether there were differences in in-hospital mortality according to the presence or absence of statin therapy in a large population of first-...

journal_title：BMC neurology

authors： Arboix A,García-Eroles L,Oliveres M,Targa C,Balcells M,Massons J

更新日期：2010-06-18 00:00:00

abstract：BACKGROUND:Anti-epileptic drugs (AEDs) are frequently prescribed to persons with HIV/AIDS receiving combination antiretroviral therapy (cART) although the extent of AED use and their interactions with cART are uncertain. Herein, AED usage, associated toxicities and immune consequences were investigated. METHODS:HIV re...

journal_title：BMC neurology

authors： Lee K,Vivithanaporn P,Siemieniuk RA,Krentz HB,Maingat F,Gill MJ,Power C

更新日期：2010-06-17 00:00:00

abstract：BACKGROUND:Neurocysticercosis (NC) is one of the most frequent parasitic diseases of the central nervous system. Cysticidal drugs, albendazole and praziquantel, are generally effective when parasites localize in the parenchyma. In contrast, parasites lodged in the subarachnoid basal cisterns are less responsive to trea...

journal_title：BMC neurology

authors： Cárdenas G,Carrillo-Mezo R,Jung H,Sciutto E,Hernandez JL,Fleury A

更新日期：2010-03-04 00:00:00

abstract：BACKGROUND:Sub-cortical vascular ischaemia is the second most common etiology contributing to cognitive impairment in older adults, and is frequently under-diagnosed and under-treated. Although evidence is mounting that exercise has benefits for cognitive function among seniors, very few randomized controlled trials of...

journal_title：BMC neurology

authors： Liu-Ambrose T,Eng JJ,Boyd LA,Jacova C,Davis JC,Bryan S,Lee P,Brasher P,Hsiung GY

更新日期：2010-02-17 00:00:00

abstract：BACKGROUND:The stability of hypoperfused brain tissue in stroke patients with major artery occlusions is unknown. The purpose of this study was to determine the persistence of a diffusion/perfusion mismatch in patients with ICA or proximal MCA occlusions. METHODS:Fourteen patients with ICA and/or proximal MCA occlusio...

journal_title：BMC neurology

authors： González RG,Hakimelahi R,Schaefer PW,Roccatagliata L,Sorensen AG,Singhal AB

更新日期：2010-02-10 00:00:00

abstract：:In clinical neurology, a comprehensive understanding of consciousness has been regarded as an abstract concept--best left to philosophers. However, times are changing and the need to clinically assess consciousness is increasingly becoming a real-world, practical challenge. Current methods for evaluating altered level...

journal_title：BMC neurology

authors： Gawryluk JR,D'Arcy RC,Connolly JF,Weaver DF

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:Previous epidemiologic studies have examined the association of smoking with amyotrophic lateral sclerosis (ALS) incidence, but their results have been inconsistent. Moreover, limited information exists on the association between smoking and survival in ALS patients. We evaluated the association of smoking w...

journal_title：BMC neurology

authors： Alonso A,Logroscino G,Jick SS,Hernán MA

更新日期：2010-01-14 00:00:00

abstract：BACKGROUND:Cannabis therapy has been considered an effective treatment for spasticity, although clinical reports of symptom reduction in multiple sclerosis (MS) describe mixed outcomes. Recently introduced therapies of combined Delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) extracts have potential for symptom ...

journal_title：BMC neurology

authors： Lakhan SE,Rowland M

更新日期：2009-12-04 00:00:00

abstract：BACKGROUND:Hemifacial atrophy (Parry-Romberg syndrome) is a relatively rare disease. The etiology of the disease is not clear. Some authors postulate its relation with limited scleroderma linearis. Linear scleroderma "en coup de sabre" is characterized by clinical presence of most commonly one-sided linear syndrome. In...

journal_title：BMC neurology

authors： Bergler-Czop B,Lis-Swiety A,Brzezińska-Wcisło L

更新日期：2009-07-27 00:00:00

abstract：BACKGROUND:Carotid angioplasty with stenting is a relatively new, increasingly used, less-invasive treatment for the treatment of symptomatic carotid artery stenosis. It is being evaluated in ongoing and nearly finished randomized trials. An important factor in the evaluation of stents is the occurrence of in-stent res...

journal_title：BMC neurology

authors： Nederkoorn PJ,Brown MM

更新日期：2009-07-22 00:00:00

abstract：:The advent of early absorption, distribution, metabolism, excretion, and toxicity (ADMET) screening has increased the attrition rate of weak drug candidates early in the drug-discovery process, and decreased the proportion of compounds failing in clinical trials for ADMET reasons. This paper reviews the history of ADM...

journal_title：BMC neurology

authors： Tsaioun K,Bottlaender M,Mabondzo A,Alzheimer's Drug Discovery Foundation.

更新日期：2009-06-12 00:00:00

abstract：BACKGROUND:Deep brain stimulation of the subthalamic nucleus significantly improves motor function in patients with severe Parkinson's disease. However, the effects on nonmotor aspects remain uncertain. The present study investigated the effects of subthalamic nucleus deep brain stimulation on mood and psychosocial fun...

journal_title：BMC neurology

authors： Kaiser I,Kryspin-Exner I,Brücke T,Volc D,Alesch F

更新日期：2008-11-11 00:00:00

abstract：BACKGROUND:Prevalence of degenerative dementias and dementias associated with cerebrovascular disease is increasing. Dementia is one of the most significant public health problem. In recent years, the role of vascular risk factors (hypertension, diabetes mellitus and hypercholesterolemia) and depression has been evalua...

journal_title：BMC neurology

authors： Fernández Martínez M,Castro Flores J,Pérez de Las Heras S,Mandaluniz Lekumberri A,Gordejuela Menocal M,Zarranz Imirizaldu JJ

更新日期：2008-10-15 00:00:00

abstract：BACKGROUND:Detecting malingering or exaggeration of impairments in brain function after traumatic brain injury is of increasing importance in neuropsychological assessment. Lawyers involved in brain injury litigation cases routinely coach their clients how to approach neuropsychological testing to their advantage. Thus...

journal_title：BMC neurology

authors： Rüsseler J,Brett A,Klaue U,Sailer M,Münte TF

更新日期：2008-10-07 00:00:00

abstract：BACKGROUND:Recent consensus guidelines recommend pregabalin as a first-tier treatment for painful diabetic peripheral neuropathy (DPN). We evaluated the efficacy of pregabalin 600 mg/d (300 mg dosed BID) versus placebo for relieving DPN-associated neuropathic pain, and assessed its safety using objective measures of ne...

journal_title：BMC neurology

authors： Arezzo JC,Rosenstock J,Lamoreaux L,Pauer L

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:Friedreich ataxia is a neurological disease originating from an iron-sulfur cluster enzyme deficiency due to impaired iron handling in the mitochondrion, aconitase being particularly affected. As a mean to counteract disease progression, it has been suggested to chelate free mitochondrial iron. Recent years ...

journal_title：BMC neurology

authors： Goncalves S,Paupe V,Dassa EP,Rustin P

更新日期：2008-06-16 00:00:00

abstract：BACKGROUND:Phase I/II placebo-controlled clinical trials of recombinant Factor VIIa (rFVIIa) suggested that administration of rFVIIa within 4 hours after onset of intracerebral hemorrhage (ICH) is safe, limits ICH growth, and improves outcomes. We sought to determine the cost-effectiveness of rFVIIa for acute ICH treat...

journal_title：BMC neurology

authors： Kissela BM,Eckman MH

更新日期：2008-05-19 00:00:00

abstract：BACKGROUND:Complaints of unrefreshing sleep are a prominent component of chronic fatigue syndrome (CFS); yet, polysomnographic studies have not consistently documented sleep abnormalities in CFS patients. We conducted this study to determine whether alterations in objective sleep characteristics are associated with sub...

journal_title：BMC neurology

authors： Majer M,Jones JF,Unger ER,Youngblood LS,Decker MJ,Gurbaxani B,Heim C,Reeves WC

更新日期：2007-12-05 00:00:00

abstract：BACKGROUND:Assessment of subjective quality of life (QOL) of persons with multiple sclerosis (MS) could facilitate the detection of psychosocial aspects of disease that may otherwise go unrecognized. The objectives of the study were to (i) compare the QOL ratings of relapsing remitting (RRMS) and progressive (PMS) type...

journal_title：BMC neurology

authors： Alshubaili AF,Awadalla AW,Ohaeri JU,Mabrouk AA

更新日期：2007-09-18 00:00:00